![]() ![]() ![]() Steroids are often a first choice of treatment to reduce inflammation.Īs physicians have gained experience in treating CRS in patients who have undergone CAR T-cell therapy, they’ve developed effective methods of preventing it or reducing its severity.ĭana-Farber physician-researchers have launched studies to determine if treatments that have proven successful in cancer therapy can also help patients with severe cases of COVID-19. To treat patients with cytokine storm, doctors pursue a three-pronged strategy: keep vulnerable organs functioning, eliminate the triggers of the overactive immune response, and use agents that can moderate or reduce that response. Nervous system problems such as headache, seizures, or even comaīecause some of these symptoms, such as fever and fatigue, can be caused by other disorders, it’s important to check with your doctor if they occur.These symptoms generally subside in a few days, although some patients may require additional treatment. These can include tremors, headaches, confusion, loss of balance, trouble speaking, seizures, and hallucinations. In some cases, CRS is followed by a second wave of neurological side effects. For most patients, the condition is mild enough that it can be managed with standard therapies such as acetaminophen and intravenous fluids. It usually arises within five days of patients’ being infused with CAR T cells. Patients who develop CRS may experience flu-like symptoms, such as high fever and/or chills, low blood pressure, or difficulty breathing. What treatments can give rise to cytokine storm?ĬAR T-cell therapy, a form of immunotherapy approved for the treatment of adults with B cell lymphoma, mantle cell lymphoma, and multiple myeloma, and children and young adults with acute lymphoblastic leukemia, is linked to cytokine release syndrome (CRS) - a form of cytokine storm - in some patients. Hemophagocytic lymphohistiocytosis, a rare disease in which white blood cells called histiocytes and lymphocytes attack other blood cells. ![]()
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